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An investigation on the tolerance and withdrawal effects of sodium valproate on anxiety in mice

โœ Scribed by DEANGELIS, L

Book ID
122594796
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
77 KB
Volume
26
Category
Article
ISSN
1043-6618

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Chronic diazepam treatment: Effect of do
Chronic diazepam treatment: Effect of dose on development of tolerance and incidence of withdrawal in an animal test of anxiety
โœ E. Sandra ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 384 KB

The effect of the treatment dose of diazepam was assessed on the rate of development of tolerance to diazepam's effects on rat behaviour in the elevated plus-maze test of anxiety. Tolerance developed more rapidly when treatment was with the higher dose: after 14 days when rats were given 2.5mg/kg/da