An Investigation of Triterpenes as Steroid Hormones

✍ Scribed by Wenzel, Duane G. ;Emick, Gilbert H.

• Book ID: 102410593
• Publisher: Elsevier
• Year: 1956
• Weight: 389 KB
• Volume: 45
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030450504

✦ Synopsis

testes and the suppression of spermatogenesis with the acetoglycerides is not understood at this time, since it has also been observed in other studies (unpublished data) with materials totally unrelated to the acetoglycerides (feather-meal protein and alle- thin). However, preliminary observations, in anather series of studies with acetoglycerides, would suggest that the testicular hypoplasia and suppression of spermatogenesis was possibly due to an insufficient amount of vitamin E in the diet in the presence of stress (acetoglycerides) rather than to other causes (peroxide formation).

Hematological studies made at approximately four-month intervals showed no toxic effect on the blood at any of the dosages of the acetoglycerides. SUMMARY 1. When acetoglycerides were administered to rats by gastric intubation in massive doses of 4 Gm./Kg., there was no evidence of any toxicity.

2. Intravenously, in rabbits, daily doses of 80 to 100 mg./Kg. of a 10% emulsion of acetostearin for fifteen days was nontoxic, had questionable effects on clotting time, and was completely removed from circulating blood within 30 minutes. Histological examination of the visceral organs showed no pathological changes.