An Investigation of the Relationship between Glass Transition Temperatures and the Crystallinity of Spray-Dried Powders
✍ Scribed by Islam, M. I. U.; Sherrell, R.; Langrish, T. A. G.
- Book ID
- 121320188
- Publisher
- Taylor and Francis Group
- Year
- 2010
- Tongue
- English
- Weight
- 636 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0737-3937
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The effect of temperature on the chemical stability of an amorphous spray-dried insulin powder formulation (Exubera) 1 was evaluated in the solid state at constant moisture content. The chemical stability of the powder was assessed using reversed-phase high-performance liquid chromatography (RP-HPLC
On the basis of microhardness (H) data measured at room temperature only for a number of polymers in the glassy state, a linear correlation between H and the glass transition temperature T g has been found (H ϭ 1.97T g Ϫ 571). By means of this relationship, the deviation of the H values from the add