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An investigation of the effects of carcinogens on Tetrahymena geleii

✍ Scribed by Tittler, Irving A.

Publisher
John Wiley and Sons
Year
1948
Tongue
English
Weight
697 KB
Volume
108
Category
Article
ISSN
0022-104X

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✦ Synopsis

The iriiportaiit discoveries of Cook and his associates ( '32) on the production of malignant tumors in laboratory animals by certain hydrocarbons opened a new and important field or' investigation in cancer research. Although much of the resultant work clealt with the effects of these hydrocarbons on tumor production in mammals, it seemed conceivable that if such compounds would also affect the cellular activities of iiiicroorganisms, these organisms might then serve a s useful tools in the study of caiicer induction, and perhaps yield'some iiiformation on the mechanism of carciiiogenesis in general.

From the studies on mammalian tumor induction it would appear that the effect of carcinogens is primarily a mutagenic one. Induced mutations have been reported in the case of many microorganisms. It would thus be possible that an investigation of the mutagenic effect of carcinogens on microorganisms might be of value in this respect.

On the other hand, a number of studies have been published from which it appears that, whether through mutations or otherwise, the known carcinogens may exert a specific effect on the growth of microbial populations which can be readily detected. However, a survey of this phase of the literature 'Fellow of the American Caneer Society on the recommendation of the Committee on Growth of the National Research Council. On leave from Biology Department,

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