An investigation of the bromination of 1,4-dihydropyridine rings

✍ Scribed by Ori Rorlik; Zeev Tashma; Claudia M. Barzilay; Morris Srebnik

• Book ID: 104098695
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 565 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.11.146

✦ Synopsis

Conditions for bromination at the C3 and C5 positions of a 1,4-dihydropyridine (DHP) were investigated. The effect of base concentration, base type, reaction temperature, and solvent were examined. DHP derivatives with ester and amide moieties were synthesized and brominated. The bromine atoms can be replaced by other substituents, utilizing Suzuki cross coupling.