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An investigation of superoxide dismutase Lys-143, Ile-143, and Glu-143 mutants: Cu2Co2SOD derivatives

✍ Scribed by Banci, Lucia.; Bertini, Ivano.; Luchinat, Claudio.; Hallewell, Robert A.

Book ID: 126162937
Publisher: American Chemical Society
Year: 1988
Tongue: English
Weight: 659 KB
Volume: 110
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja00219a043

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The activity profile of the Cu2Zn2HSOD Ile-137 mutant has a pKa of 9.6, i.e. one unit lower than the wild type (WT). This property has allowed us to investigate the inactive high pH form of the enzyme before denaturation occurs. The electronic and EPR spectra do not change with the above pKa. The 1H