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An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva

✍ Scribed by Marie-Anne Félix


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
121 KB
Volume
27
Category
Article
ISSN
0265-9247

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✦ Synopsis


Signal transduction pathways are largely conserved throughout the animal kingdom. The repertoire of pathways is limited and each pathway is used in different intercellular signaling events during the development of a given animal. For example, Wnt signaling is recruited, sometimes redundantly with other molecular pathways, in four cell specification events during Caenorhabditis elegans vulva development, including the activation of vulval differentiation. Strikingly,a recent study finds that Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus,1 demonstrating evolutionary flexibility in the use of intercellular signaling pathways.


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