An intermediate pathway of cell death involving cathepsin D during tumor necrosis factor-α-induced apoptosis
✍ Scribed by T.A. Womble; D.C. Lee; I.N. Jackson; C.A. Mason; B.A. Smith; N. Anderson; D.E. Palm
- Book ID
- 116458868
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 63 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0014-4886
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Intravenous administration of tumor necrosis factor-alpha (TNF-alpha) (0.5 microg/mouse) caused hepatocyte apoptosis in BALB/c mice when they were sensitized with D-galactosamine (GalN, 20 mg/mouse). Activation of nuclear factor kappa B (NF-kappa B) and expression of apoptotic Bcl-2 family members w
## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl