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An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer

✍ Scribed by Stemke-Hale, K.; Gonzalez-Angulo, A. M.; Lluch, A.; Neve, R. M.; Kuo, W.-L.; Davies, M.; Carey, M.; Hu, Z.; Guan, Y.; Sahin, A.; Symmans, W. F.; Pusztai, L.; Nolden, L. K.; Horlings, H.; Berns, K.; Hung, M.-C.; van de Vijver, M. J.; Valero, V.; Gray, J. W.; Bernards, R.; Mills, G. B.; Hennessy, B. T.

Book ID
121720571
Publisher
American Association for Cancer Research
Year
2008
Tongue
English
Weight
446 KB
Volume
68
Category
Article
ISSN
0008-5472

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## Abstract Mutation of __PIK3CA__, the gene coding for the p110Ξ± catalytic subunit of phosphoinositide 3‐kinase (PI3K), has been reported in a limited range of human tumors. We now report that __PIK3CA__ is also mutated in esophageal tumors. Single‐strand conformational polymorphism (SSCP) and den