Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of raeemie 5 using ruthenium-BINAP-diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2-methoxycyclohexanone [(S)-5] reacts with the 4-aeetoxyazetidinone 4 to give the key int
An Integrated Chemo-enzymatic Route for Preparation of β-Thymidine, a Key Intermediate in the Preparation of Antiretrovirals
✍ Scribed by Gordon, Gregory E. R.; Bode, Moira L.; Visser, Daniel F.; Lepuru, M. Jerry; Zeevaart, Jacob G.; Ragubeer, Nasheen; Ratsaka, Molala; Walwyn, David R.; Brady, Dean
- Book ID
- 126073002
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 829 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1083-6160
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Methyl ~-piperonylhemisuccinate was resolved into both its (R)-(t) and (S)-(-Iantipodes by (-) and (+)-ephedrine, respectively. Calcium borohydride reduction of the (R)-(t) and (S)-(-)-hemiesters afforded the crystalline, o.ptically pure, (R)-(t) and (S)-t-k B-piperonyl-y-butyrolactones, respectivel