An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

An intact retinoblastoma protein-binding

An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells

✍ Roland Houben; Christian Adam; Anne Baeurle; Sonja Hesbacher; Johannes Grimm; Sa 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 934 KB

## Abstract Merkel cell carcinoma (MCC) is a highly aggressive skin cancer that frequently harbours Merkel cell polyomavirus (MCV) DNA integrated in the genome of the tumor cells. In our study, we elaborate our recent finding that MCV‐positive MCC cell lines require the expression of the viral T an