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An Inhibitor of Cell Proliferation Released by Cultures of Macrophages

โœ Scribed by Jesus Calderon, Richard T. Williams and Emil R. Unanue

Book ID
123652905
Publisher
National Academy of Sciences
Year
1974
Tongue
English
Weight
831 KB
Volume
71
Category
Article
ISSN
0027-8424

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5'-Met h ylt h ioadenosi n e (MTA) is formed from decarboxylated S-adenosyl methionine during biosynthesis of polyamines. This nucleoside is cleaved by methylthioadenosine phosphorylase (MTA Pase) to adenine and 5-methylthioribose-I-phosphate in mammalian cells. 5'-Difluoromethylthioadenosine (DFMTA