An informativity index for multilocus DNA fingerprints

✍ Scribed by PD Dr. Michael Krawczak; Thomas Lubjuhn

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 642 KB
• Volume: 16
• Category: Article
• ISSN: 0173-0835
• DOI: 10.1002/elps.1150160105

✦ Synopsis

An informativity index for multilocus DNA fingerprints, r, was developed. It is based upon the Shannon information that a paternal DNA fingerprint conveys about the offspring phenotype pattern. Both simulation and empirical data reveal that the index r is strongly correlated with the mean log likelihood ratio (paternity vs. nonpaternity) expected in trio cases of true paternity. Since r can be estimated from DNA fingerprints of unrelated individuals in advance, it will provide an easy means to assess the potential utility of a given probe/ enzyme combination in kinship testing.