๐”– Bobbio Scriptorium
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An index of fatal toxicity for drugs of misuse

โœ Scribed by Leslie A. King; John M. Corkery

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
90 KB
Volume
25
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

โœฆ Synopsis

Abstract

Objective

To determine the lethal toxicity of five commonlyโ€used illicit substances by relating the number of associated deaths to their availability.

Methods

An index of toxicity was calculated for each of five drugs [heroin, cocaine/crack, ecstasy (MDMA), amphetamine and cannabis] as the ratio of the number of deaths associated with that substance to its availability in the period 2003โ€“2007. Three separate proxy measures of availability were used (number of users as determined by household surveys, number of seizures by law enforcement agencies and estimates of the market size). All data are related to England and Wales only.

Results

There was a broad correlation between all three denominators of availability. Not unexpectedly, heroin and cannabis showed, respectively, the highest and lowest toxicities. The index of fatal toxicity of MDMA was close to that of amphetamine and cocaine/crack. There was a rank correlation between this index and other measures of lethal toxicity based on safety ratios.

Conclusions

These results are contrary to widelyโ€held public views of the relative fatal toxicity of MDMA. Copyright ยฉ 2010 John Wiley & Sons, Ltd.

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