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An increased ratio of interleukin-1 receptor antagonist to interleukin-1α in inflammatory skin diseases

✍ Scribed by T. Terui; T. Hirao; Y. Sato; T. Uesugi; M. Honda; M. Iguchi; N. Matsumura; K. Kudoh; S. Aiba; H. Tagami

Book ID
111243877
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
128 KB
Volume
7
Category
Article
ISSN
0906-6705

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## Abstract Interleukin 1 (IL‐1) is a major mediator of inflammation and exerts pleiotropic effects on many systems. To elucidate the role of its endogenous inhibitor, intracellular IL‐1 receptor antagonist (icIL‐1Ra), in mouse skin, we produced an icIL‐1Ra–overexpressing skin carcinoma cell line (