✦ LIBER ✦

An in vitro model of alcohol and acetaldehyde teratogenicity

✍ Scribed by P. A. C. Thompson; P. I. Folb

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 424 KB
Volume: 2
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550020404

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

C~3~H mouse embryos were supported in an in vitro culture system over 28‐h periods between 8 and 10 days post‐conception. Morphological development over this critical period of organogenesis was monitored in the following respects: somite count; presence or absence of heart beat; central nervous system size and symmetry; neural tube fusion. Total embryo DNA synthesis, determined by ^3^H‐thymidine uptake of the embryo over the last 4 h of the culture period, was compared with morphological findings. The effects of varying concentrations of ethanol and acetaldehyde, respectively, on morphology and DNA synthesis were determined at the dose levels tested. Both ethanol and acetaldehyde were toxic to the mouse embryos at this stage of their development, and reasonably close correlation was found between morphological abnormalities and reduction in DNA synthesis.

📜 SIMILAR VOLUMES

Sequential acetaldehyde production, lipi

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

✍ Onni Nlemelä; Seppo Parkkila; Seppo Ylä-herttuala; Jesus Villanueva; Boris Ruebn 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 823 KB

The pathogenesis of alcohol-induced liver disease involves the adverse effects of ethanol metabolites and oxidative tissue injury. Previous studies indicated that covalent protein adducts with reactive aldehydes may be formed in alcohol consumers. To study the role of such protein adducts in the dev

Acetaldehyde accumulation in rat mammary

Acetaldehyde accumulation in rat mammary tissue after an acute treatment with alcohol

✍ G. D. Castro; A. M. A. Delgado de Layño; S. L. Fanelli; M. E. Maciel; M. I. Díaz 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

## Abstract Previous studies reported the presence in rat mammary tissue of a cytosolic xanthine oxidoreductase pathway for the metabolism of alcohol to acetaldehyde and hydroxyl radicals and to the microsomal biotransformation of ethanol to acetaldehyde. It was also reported that after chronic eth

Model predicting the teratogenic potenti

Model predicting the teratogenic potential of retinyl palmitate, using a combined in vivo/in vitro approach

✍ Ritchie, H. E.; Webster, W. S.; Eckhoff, C.; Oakes, D. J. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 2 views

Retinyl palmitate (RP) is a known laboratory animal teratogen inducing abnormalities of the second visceral arch when administered on day 9 of gestation in the rat. However, there are significant problems when attempting to extrapolate this result to the human. A combined in vivo/in vitro model was

Teratogenic effects of bis-diamine on ea

Teratogenic effects of bis-diamine on early embryonic rat heart: An in vitro study

✍ Nishijima, Setsuko ;Nakagawa, Masao ;Fujino, Hidetoshi ;Hanato, Takashi ;Okamoto 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 449 KB 👁 2 views

Background: Bis-diamine induces cardiac defects, including conotruncal anomalies in rat embryos when the agent is administered to the mother. To evaluate the teratogenic effects and mechanism of bis-diamine, we performed morphological and immunohistochemical analyses of early rat embryos cultured in

Immunotoxicity of pyrethroid metabolites

Immunotoxicity of pyrethroid metabolites in an in vitro model

✍ Ying Zhang; Meirong Zhao; Meiqing Jin; Chao Xu; Cui Wang; Weiping Liu 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB

## Abstract Risk assessment of man‐made chemicals such as pesticides are mainly focused on parent compounds, and relatively little is known about their metabolites, especially with regard to target organ damages such as immunotoxicity. In the present study, the immunotoxicity of five synthetic pyre

Synergistic effect of alcohol drinking a

Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva

✍ Ville Salaspuro; Mikko Salaspuro 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 84 KB

## Abstract Alcohol drinking and smoking are independent risk factors for upper digestive tract cancers. Furthermore, their combined use interacts in a multiplicative way on cancer risk. There is convincing evidence that acetaldehyde, the first metabolite of ethanol and a constituent of tobacco smo