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An in vitro model for the study of microglia-induced neurodegeneration: involvement of nitric oxide and tumor necrosis factor-α

✍ Scribed by Karin Hemmer; Lucie Fransen; Hugo Vanderstichele; Eugeen Vanmechelen; Paul Heuschling


Book ID
117409624
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
237 KB
Volume
38
Category
Article
ISSN
0197-0186

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## Abstract Trimethyltin (TMT) is a neurotoxicant known to induce early microglial activation. The present study was undertaken to investigate the role played by these microglial cells in the TMT‐induced neurotoxicity. The effects of TMT were investigated in monolayer cultures of isolated microglia