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An in vitro clonal assay for bladder cancer: Studies of the biologic potential of the urothelium and determination of in vitro sensitivity to cytotoxic agents

โœ Scribed by T. H. Stanisic; R. N. Buick; J. M. Trent; S. E. Fry; S. E. Salmon


Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
249 KB
Volume
18
Category
Article
ISSN
0022-4790

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## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3โ€methoxymorphinan and 3โ€hydroxymorphinan, i