In order to obtain diastereomeric control in the azole catalyzed coupling reaction of methylphosphonamidites, 2-(2",4",6"-trimethylbiphenyl-2-yl)-4,5-dicyanoimidazole 2 was synthesized. With its use as activator Rp-diastereoselective synthesis of dinucleoside methylphosphonates could be achieved for
An improvement in the stereospecific synthesis of dinucleoside methylphosphonates
โ Scribed by James F. Cormier; Tina Pannunzio
- Book ID
- 103397843
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 251 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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A P" coupling reagent 3 containing indole group is described. Its usefulness is demonstrated by the synthesis of dinucleoside methylphosphonates and methylthiophosphonates. 8 1997 Elsevier Science Ltd. The oligonucleoside methylphosphonates (MP) show significant potential for antisense therapy.' The