An improved Williamson etherification of hindered alcohols promoted by 15-crown-5 and sodium hydride

✍ Scribed by Helen C. Aspinall; Nicholas Greeves; Wai-Man Lee; Edward G. McIver; Peter M. Smith

• Book ID: 104257324
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 179 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00965-9

✦ Synopsis

IS-crown-5 greatly facilitates Williamson ether synthesis when sodium hydride base is used in THF solvent. This mild yet versatile procedure has been employed in the synthesis of new homochiral polyether ligands and bis-allylic ethers which are inaccessible by conventional methods.