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An improved technique for the preparative electrophoresis and electroelution of high molecular weight ribosomal RNA

✍ Scribed by Rose Ann Cattolico; Raymond F. Jones


Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
648 KB
Volume
66
Category
Article
ISSN
0003-2697

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✦ Synopsis


A new technique for casting flat 0.5% agarose-2.4% acrylamide preparative gels is described in this communication. The casting method presented completely eliminates mechanical problems and technical complications often encountered in producing the homogeneous loading platform critical to the entrance and proper migration of RNA species on low pore composite gels. The gels formed can be used to separate milligram quantities of RNA with excellent resolution and a method for the electroelution of a specific RNA species is also presented.