✦ LIBER ✦
An improved synthesis of UDP-3-O-acyl-N-[3H-acetyl]glucosamine: a probe for inhibitors of LpxC in gram-negative bacteria
✍ Scribed by Brad D. Maxwell; Joel C. Bronstein
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- French
- Weight
- 102 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
UDP-3-O-(R-3-hydroxydecanoyl)-N-[ 3 H-acetyl]glucosamine, was prepared using a modified procedure for the preparation of carboxamides reported by Kunishima et al. using [ 3 H]CH 3 CO 2 Na, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, N-methylmorpholine and UDP-3-O-(R-3-hydroxydecanoyl)glucosamine in 26% overall yield. Full details of the synthesis and the analysis of the product are presented.