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An Improved Synthesis of the Selenium Analogs of Methionine and Homocystine 1

โœ Scribed by Klosterman, Harold J.; Painter, Edgar Page


Book ID
126245712
Publisher
American Chemical Society
Year
1947
Tongue
English
Weight
258 KB
Volume
69
Category
Article
ISSN
0002-7863

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We synthesized the selenium analog of glutathione disulfide by a liquid phase method and named it glutaselenone (i.e., gamma-L-glutamyl-L-selenocysteinylglycine) diselenide. The selenol of selenocysteine was protected by the p-methoxybenzyl group, which was removed by acidolysis with trifluoroacetic