An improved synthesis of N-acetoxy-N-acetyl-2-aminofluorene-9-14C using an extractive acylation technique

✍ Scribed by M. R. Thissen; W. P. Duncan

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: French
• Weight: 207 KB
• Volume: 15
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580150109

✦ Synopsis

A rapid, high yield (90-100%) method for the preparation of N-a~etoxy-N-acetyl-2-aminofluorene-9-~~C (N-AcO-AAF-9-14C) from N-hydroxy-N-a~etyl-2-aminofluorene-9-~~C (N-OH-AAF-9-14C) is described. The procedure conrists of the in situ formation of a quaternary amonium salt of N-OH-AAF-9-lq in a two-phase system and subiequent acetylation of this salt with acetic anhydride. The specific activity of the product was 40.6 mCifoPmole.