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An Improved Synthesis of Memantine Hydrochloride: Anti-Alzheimer's Drug †

✍ Scribed by Reddy, Jambula Mukunda; Prasad, Ganji; Raju, Veeramalla; Ravikumar, Mylavarapu; Himabindu, Vurumidi; Reddy, Ghanta Mahesh

Book ID
119979241
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
31 KB
Volume
11
Category
Article
ISSN
1083-6160

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## Abstract An efficient route for the synthesis of (−)‐physostigmine analogs **1a**–**1g** and **2a**–**2k** is described. Analogs **1a**–**1g** were synthesized __via__ copper(I)‐catalyzed cycloaddition between the optically pure azide **10** and a variety of alkynes. Similarly, analogs **2a**–**