An improved synthesis of a fluorescent gabapentin–choline conjugate for single molecule detection

✍ Scribed by Haitao Wu; Gurpreet Kaur; Gary L. Griffiths

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 287 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.02.125

✦ Synopsis

Voltage-gated calcium ion channels are comprised of pore-forming α(1) and auxiliary α(2)δ, β and γ subunits. They are important molecular devices involved in a variety of cell functions. Fluorescently labeled acylcholine analogues are important in studies such as ion channel regulation. Cy3-3-acetylcholine has recently been synthesized for single molecule detection studies; albeit in an extremely low overall yield (0.06 %). In this work, an alternative route to that used in the previous Cy3-3-acetylcholine synthesis was developed with a 90 % yield at a significantly lower material cost.