✦ LIBER ✦

An improved synthesis of 7-nitrobenz-2-oxa-1,3-diazole analogs of CDP-diacylglycerol and phosphatidylinositol

✍ Scribed by Anthony E. Ting; Richard E. Pagano

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 625 KB
Volume: 60
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(91)90018-7

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✦ Synopsis

A protocol utilizing chemical and enzymatic steps to synthesize several fluorescent (7-nitrobenz-2-oxa-l,3 diazole) analogs of cytidine diphosphate diacylglycerol and phosphatidylinositol in high yields is described. The fluorescent analogs were characterized by phospholipase C digestion, fast atom bombardment mass spectrometry, and HPLC analysis. Studies of the metabolism and intracellular distribution of the fluorescent phosphatidylinositol analogs in Swiss 3T3 cells further revealed that all the analogs were substrates for a previously described cell surface phosphatidylinositol-specific phospholipase C (A.E.

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