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An improved synthesis of (4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine

✍ Scribed by Ivan C. Nordin; James A. Thomas

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
99 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

The title compound is prepared in 78% yield using an improved one-pot procedure which does not require final purification.

The title compound (4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-amine ( 1) is an effective reagent for the synthesis of optically active amino acids (2)l and d-methyl amino acids (3Jzs3 as shown in Scheme 1. The literature methods for the synthesis of 1 use a reaction scheme similar to Scheme 2, reporting 36X4 and 56X5 yields of1, depending on work-up conditions.

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