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An improved synthesis of 1α, 25-dihydroxyvitamin D A synthons

✍ Scribed by L Castedo; J.L Mascareñas; A Mouriño


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
228 KB
Volume
28
Category
Article
ISSN
0040-4039

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✍ Masakazu Koiwa; Georges P.J Hareau; Fumie Sato 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 99 KB

The asymmetric synthesis of the A-ring of 1α,25-dihydroxyvitamin D 3 , (Z)-2, from 5-tert-butyldimethylsiloxy-2-cyclohexenone [(S)-1], is described where an intramolecular lactonization using cat. scandium triflate is the key reaction.