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An Improved Protocol for Dihydropyrimidines Synthesis

✍ Scribed by Srivastava, Vivek


Book ID
121611824
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
160 KB
Volume
36
Category
Article
ISSN
0250-541X

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A simple and effective synthesis of 3,4-dihydropyrimidinone derivatives from aldehydes, 1,3-dicarbonyl compounds, and urea/thiourea in ethanol by using calcium fluoride as catalyst has been described. Compared with classical Biginelli reaction conditions, this new method has the advantage of excelle