An Improved Procedure for the Three-Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid
✍ Scribed by Ranu, Brindaban C.; Jana, Ranjan; Sowmiah, S.
- Book ID
- 115467185
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 75 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3263
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## Abstract A basic ionic liquid, 1‐butyl‐3‐methyl imidazolium hydroxide ([bmim]OH), efficiently promotes a one‐pot, three‐component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate, and 2‐hydroxy‐1,4‐naphthoquinone to produce 4‐aryl‐5,10‐dihydro‐4__H__‐benzo[__g__]chromene‐5
## Abstract magnified image Three‐component coupling of aldehydes, malononitrile, and thiophenols has efficiently been carried out at room temperature using potassium fluoride on alumina (KF·Al~2~O~3~) as a catalyst to furnish highly substituted pyridines in high yields. J. Heterocyclic Chem., (200