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AN IMPROVED PROCEDURE FOR THE PREPARATION AND RESOLUTION OF dl-2,3-DIMETHYLSUCCINIC ACID

✍ Scribed by Sutton, Scott C.; Nantz, Michael H.; Hitchcock, Shawn R.


Book ID
121291101
Publisher
Taylor and Francis Group
Year
1992
Tongue
English
Weight
325 KB
Volume
24
Category
Article
ISSN
0030-4948

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## Abstract A convenient two‐step chemical synthesis of DL‐[2‐^13^C]‐glutamic acid from methyl acrylate and diethyl acetamidomalonate is described. Synthesis of the Michael adduct (III) was effected in quantitative yield by employing strong amino bases as catalysts. The reactivities of three such c