An improved model of acetaminophen-induc
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James H. Kelly; Tarek Koussayer; Da-Er He; Maria G. Chong; Thomas A. Shang; Hart
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Article
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1992
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John Wiley and Sons
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English
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We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 pg/ml for 20 hr. This regimen produces sever