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An Improved Method for the Preparation of Morphenol (3-Hydroxy-4,5-phenanthrylene Oxide) from Morphine 1

โœ Scribed by Mosettig, Erich; Meitzner, Erich


Book ID
127128564
Publisher
American Chemical Society
Year
1934
Tongue
English
Weight
356 KB
Volume
56
Category
Article
ISSN
0002-7863

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Hydroxy-1-phenylthio-2-alkynes (5) reacted with dihydropyran to afford the corresponding 4-tetrahydropyranyloxy derivatives which, on treatment with KHMDS, gave a mixture of (E)-and (Z)-1-phenylthio-3-alken-1-ynes, with the former predominant. When MeLi was used in the place of KHMDS, the (Z)-isomer