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An improved method for the generation of imines and enamides. Application to the synthesis of 3-arylisoquinoline derivatives

✍ Scribed by Nuria Sotomayor; Teresa Vicente; Esther Domínguez; Esther Lete; María-Jesús Villa


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
984 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis


The one-not oreoaration of hindered 1%diawlethvlamines 3 and 4 and etbvlenenamides 5 is achieved vfa . . sodium cyanoborohydride reduction and acylation of thedeox;benzoin imines 2, respectively. A new methodology for the synthesis of 3arylisoquinolinium salts by the Bischler-Napieralski reaction of 1,2-diarylethylenenamides and their transformation into 12-methyl substituted benzo[c]phenanthridines has been developed.


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