An improved method for the formation of formaldehyde acetal derivatives from annonaceous acetogenins

✍ Scribed by Emerson F. Queiroz; Edna L.M. Silva; François Roblot; Reynald Hocquemiller; Bruno Figadère

• Book ID: 104260487
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 190 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)02484-8

✦ Synopsis

Preparations of 1,2-, 1,3-, 1,5-formaldehyde acetals from the corresponding polyhydroxylated annonaceous acetogenins were performed in good yield. Addition of Et3N to a mixture of DMSO and TMSC1 is crucial to avoid in situ hydrolysis of the intramolecular acetals.