An improved method for studying the psychogalvanic reaction in mice and its inhibition by psycholeptic drugs. Comparison with the effects of other pharmacological agents
✍ Scribed by R. Marcy; M. A. Quermonne
- Publisher
- Springer
- Year
- 1974
- Tongue
- English
- Weight
- 733 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
✦ Synopsis
An apparatus and a quantitative method for studying the spontaneous palmar conductivity (SPC) and the psychogalvanic reaction (PGR) in mice are described. Several psyeholepties (neuroleptics, tranquillizers, hypnotics) were tested. In order to assess the specificity of the method, several other pharmacological agents (muscle relaxants, neuromnsclar blocking agents, anticholinergics, cr lyrics) were tested.
A comparison of the active doses of these various products on SPC, PGR, prehension and traction reflexes shows that psycholeptics and more particularly neuroleptics and tranquillizers inhibit PGR at low dosages. These are smaller than the motor test inhibitory dosages and far lower than LDS0.
Providing one discounts drugs inhibiting the PGR by peripheral anticholinergic or adrenolytie activity and those which inhibit the PGI~ at dosages which are similar to the motor depressant dosages, the method is valid for screening and studying psycholeptic drugs.