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An improved method for hyaluronic acid radioiodination

✍ Scribed by P. Orlando; L. Binaglia; A. De Feo; M. Orlando; R. Trenta; R. Trevisi

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
213 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A simple procedure is described for preparing ^125^I‐labelling hyaluronan of high molecular weight. The reducing terminal group of hyaluronic acid was derivatized with tyramine through the formation of a Schiff base which was subsequently reduced with sodium cyanoborohydride.

By radioiodination of the aromatic ring, ^125^I‐labelled hyaluronic acid was obtained in high yield (40%) and high specific activity, 555 GBq/mmol (15 Ci/mmol).

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