𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An improved method for [5′-2H]-labelling 3′-O-acetylthymidine

✍ Scribed by John Orban; Brian R. Reid

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
196 KB
Volume
27
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

3'-0Acetylthymidine (I) was converted to the 0-acetoxy aldehyde (3) using a modified Swern oxidation procedure. The crude product was reduced with sodium borodeuteride to give, after chromatography, [5'-2H]-3'-CL-acety1thymidine (4) in 68% overall yield from -1. The extent of deuterium incorporation was >95% as judged by 'H NMR spectroscopy.

📜 SIMILAR VOLUMES

Improved titanium method for determinati
Improved titanium method for determination of atmospheric H2O2
✍ Massimiliano Possanzini; Vincenzo Di Palo 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 494 KB

Gaseous H,O, is sampled on a Ti(IV)-H,SO, coated filter, where titanium peroxy complex is formed. After sampling the filter is leached in a phosphate buffer (pH 7) and the peroxide concentration analysed spectrophotometrically at 505 nm after having added 4-(2-pyridylazohesorcinol (PAR). The triple