✦ LIBER ✦

An improved high-pressure liquid chromatographic assay for 2-acetylaminofluorene and eight of its metabolites

✍ Scribed by Carole L. Smith; Snorri S. Thorgeirsson

Publisher: Elsevier Science
Year: 1981
Tongue: English
Weight: 492 KB
Volume: 113
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(81)90044-0

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✦ Synopsis

A high-pressure liquid chromatography method utilizing desferal mesylate as a solvent additive was developed for the simultaneous separation of 2-acetylaminofluorene, N-hydroxy-2-acetylaminofluorene, 9-hydroxy-2-acetylaminofluorene, 7-hydroxy-2-acetylaminofluorene, 5-hydroxy-2-acetylaminofluorene, 3-hydroxy-2-acetylaminofluorene, I-hydroxy-2acetylaminofluorene, 2-aminofluorene, and 2-acetylaminofluorene-9-one.

The method was used to quantitate these metabolites formed when 2-acetylaminofluorene was incubated with freshly isolated rat liver cells, with rat liver microsomes or with microsomes prepared from isolated hepatocytes.

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