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An improved flow cytometric assay for somatic mutations at the glycophorin A locus in humans

โœ Scribed by Richard G. Langlois; Barbara A. Nisbet; William L. Bigbee; David N. Ridinger; Ronald H. Jensen

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
954 KB
Volume
11
Category
Article
ISSN
0196-4763

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Direct immunofluorescence labeling provi
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โœ Ronald H. Jensen; William L. Bigbee ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 688 KB

The glycophorin A (GPA) somatic cell mutation assay is being applied widely as an in vivo biomarker in molecular epidemiologic studies of human populations. The assay uses two-color immunolabeling and flow cytometry of peripheral blood samples to enumerate allele-loss variant erythrocytes that appea