✦ LIBER ✦

An improved and practical synthesis of 4-fluorobenzaldehyde by halogen-exchange fluorination reaction

✍ Scribed by Yasuo Yoshida; Yoshikazu Kimura

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 392 KB
Volume: 44
Category: Article
ISSN: 0022-1139
DOI: 10.1016/s0022-1139(00)83946-9

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✦ Synopsis

A process which can afford a large quantity of 4-fluorobenzaldehyde was developed from halogen-exchange of 4-chlorobenzaldehyde with potassium fluoride in aromatic hydrocarbon solvents in the presence of tetraphenylphosphonium bromide plus polyethylene glycol dimethyl ether. The features of the reaction are discussed.

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