It is well established that the activation of proto-oncogenes could trigger uncontrolled cell growth and cancer development. Although this correlation has already been evidenced in several human tumors, no conclusive studies have related oncogene activation with the development of prostatic neoplasi
An immunohistochemical study of the incidence and significance of C-erbB-2 oncoprotein overexpression in ovarian neoplasia
β Scribed by N. WILKINSON; N. TODD; C.H. BUCKLEY; B.A. GUSTERSON; H. FOX
- Book ID
- 109085239
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 433 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1048-891X
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## Background: The c-erbb-2 gene codes for a putative transmembrane protein, similar in structure to the epidermal growth factor receptor. amplification and/or overexpression of the gene has been recently described with a prognostic significance in a variety of human adenocarcinomas. ## Methods:
## Abstract An immunohistochemical study of the cβerbBβ2 protein was conducted on formalinβfixed paraffinβembedded tissue sections from 136 primary gastric carcinomas and 50 metastatic lymph node tumors obtained at gastrectomy. Expression of the protein was detected in 35 of 136 primary gastric car