𝔖 Bobbio Scriptorium
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An illustration of the use of isotopes: The biosynthesis of porphyrins

✍ Scribed by David Shemin

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
768 KB
Volume
10
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

In this article, David Shemin, who is now in retirement, describes how in 1944 he ingested 6 6 g of I5N-labeled glycine in order to determine the half-lge of hemoglobin and other blood proteins. The ramifcations of the experiment led to the unravelling of the biosynthesis of porphyrins and the role of glycine and a-aminolevulinic acid in heme, vitamin

B,, and chlorophyll synthesis.

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