An HPLC procedure for the enantiomeric purity of an optically active cytosine analogue using ligand exchange

✍ Scribed by Edward J. Pack JR.; Bonnie Bleiberg; Ira E. Rosenberg

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 389 KB
• Volume: 2
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.530020414

✦ Synopsis

An acylonucleotide analogue, 1-[3-hydroxy-2-(phosphonylmethoxy)propyllcytosine (HPMPC), has shown activity against herpes simplex Type I and Type I1 viruses. An HPLC separation of the Rand S-enantiomers of HPMPC by ligand exchange using a mobile phase containing phenylalanine as the chiral modifier and copper(I1) as the metal ion is reported.