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An HPLC-linked assay of phosphoribosylpyrophosphate synthetase activity in the erythrocytes of adults and children with neurological disorders

✍ Scribed by Vanna Micheli; Marina Rocchigiani; Giuseppe Pompucci


Book ID
115828018
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
554 KB
Volume
227
Category
Article
ISSN
0009-8981

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## Abstract A novel assay for the determination of l‐asparaginase activity in human plasma is described that is based on the HPLC quantitation of l‐aspartic acid produced during enzyme incubation. Methods for monitoring l‐asparagine depletion are also described. Chromatography of l‐aspartic acid, l