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An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1

✍ Scribed by Sörby, Maria; Sandström, Jill; Östman, Arne


Book ID
110064844
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
238 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin