𝔖 Bobbio Scriptorium
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An exploration of the primary specificity site of cathepsin B

✍ Scribed by Elliott Shaw; Peter Wikstrom; John Ruscica

Book ID
115705870
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
476 KB
Volume
222
Category
Article
ISSN
0003-9861

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## Abstract Cathepsin B is a cysteine protease that in tumor tissues is localized in both acidic lysosomes and extracellular spaces. It can catalyze the cleavage of peptide bonds by two mechanisms: endoproteolytic attack with a pH optimum around 7.4, and attack from the __C__‐terminus with a pH opt