✦ LIBER ✦
An explanation for the failure of aminomethanesulfonic acid to form sulfonamides. Acyl chloride-promoted generation of α-carboxamidoalkylating electrophiles.
✍ Scribed by Gregory R. Moe; Lawrence M. Sayre; Philip S. Portoghese
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 235 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Attempted N,N-dibenzoylation of aminomethanesulfonic acid results in C-S bond cleavage, generating synthetically useful a-bensamidomethylatinq electrophiles. The importance of this observation in regard to the reported failures to prepare sulfonamide analogs of peptides is discussed.