Nanofluid is a new class of heat transfer fluids engineered by dispersing metallic or non-metallic nanoparticles with a typical size of less than 100 nm in the conventional heat transfer fluids. Their use remarkably augments the heat transfer potential of the base liquids. This article presents the heat transfer coefficient and friction factor of the TiO 2 -water nanofluids flowing in a horizontal double tube counter-flow heat exchanger under turbulent flow conditions, experimentally. TiO 2 nanoparticles with diameters of 21 nm dispersed in water with volume concentrations of 0.2-2 vol.% are used as the test fluid. The results show that the heat transfer coefficient of nanofluid is higher than that of the base liquid and increased with increasing the Reynolds number and particle concentrations. The heat transfer coefficient of nanofluids was approximately 26% greater than that of pure vol.%, and the results also show that the heat transfer coefficient of the nanofluids at a volume concentration of 2.0 vol.% was approximately 14% lower than that of base fluids for given conditions. For the pressure drop, the results show that the pressure drop of nanofluids was slightly higher than the base fluid and increases with increasing the volume concentrations. Finally, the new correlations were proposed for predicting the Nusselt number and friction factor of the nanofluids, especially.